A recently published paper, led by Dr. Jim Mulshine, MD, and co-authored by distinguished researchers from around the world, aligns with HeartLung's mission of offering chest CT-based innovative AI solutions for early detection of heart disease, lung cancer, emphysema/COPD, fatty liver disease, and other fatal conditions to millions of people who need it.
Many of the co-authors were speakers at the 1st Conference on Integrating Early Detection of Heart and Lung Disease through Low-Dose CT, including HeartLung's scientific advisors: Dr. Morteza Naghavi, MD, Dr. David Yankelevitz, MD, and Dr. Claudia Henschke, PhD, MD, Dr. Anthony Reeves, PhD, and Dr. Javier Zulueta, MD.
Authors:
James L. Mulshine, Bruce Pyenson, Cheryl Healton, Carolyn Aldige, Riccardo S. Avila, Torsten Blum, Matthew Cham, Harry J. de Koning, Sean B. Fain, John K. Field, Raja Flores, Maryellen L. Giger, Ilya Gipp, Frederic W. Grannis, Jan Willem C. Gratama, Ella A. Kazerooni, Karen Kelly, Harriet L. Lancaster, Luis Montuenga, Kyle J. Myers, Morteza Naghavi, Raymond Osarogiagbon, Ugo Pastorino, Anthony P. Reeves, Albert Rizzo, Sheila Ross, Victoria Schneider, Luis M. Seijo, Dorith Shaham, Mario Silva, Robert Smith, Emanuela Taioli, Kevin ten Haaf, Carlijn M. van der Aalst, Lucia Viola, Jens Vogel-Claussen, Anna N.H. Walstra, Ning Wu, Pan-Chyr Yang, Rowena Yip, David F. Yankelevitz, Claudia I. Henschke, Matthijs Oudkerk, Paradigm shift in early detection: Lung cancer screening to comprehensive CT screening, European Journal of Cancer, Volume 218, 2025, 115264, ISSN 0959-8049, https://doi.org/10.1016/j.ejca.2025.115264.
Abstract:
Large-scale lung cancer screening implementation combined with improvements in early detection techniques for three major tobacco-related diseases presents a rare opportunity to markedly improve population health outcomes for millions of people. Chest CT enables routine detection of early lung cancer as well as characterizing coronary calcium and detecting early emphysema in the course of lung cancer screening. Integrated preventive care centered on comprehensive chest CT screening has the potential to bring large benefits across co-morbid diseases with a common etiology. The current one-disease/ silo paradigm of medical practice is an obstacle to maximizing chest CT screening’s benefits.
The large potential for improved health outcomes across the world demands careful public health, quality assurance, and health policy considerations. A systematic analysis of imaging and health data from ongoing chest CT screening could accelerate this paradigm shift through sustained optimization of screening detection, quantitation and management for the three most lethal tobacco-related co-morbidities. To coordinate this effort to advance progress with implementing the full benefit of comprehensive chest CT screening, a new multi-disciplinary professional and advocacy consortium has been developed to foster collaboration to realize the future of multi-disease chest CT screening.
Background/Objectives:
Preventive cardiology focuses on reducing the risk of cardiovascular diseases through early detection and lifestyle modifications. The primary objective of this study is to evaluate the effectiveness of a new intervention in reducing cardiovascular risk factors among high-risk populations.
Methods:
The study utilized a randomized controlled trial design, involving participants with identified cardiovascular risk factors. Participants were divided into intervention and control groups. The intervention group received a comprehensive lifestyle modification program, including dietary changes, physical activity, and stress management techniques. Data were collected at baseline, 6 months, and 12 months to assess changes in cardiovascular risk factors.
Results:
The intervention group showed significant improvements in key cardiovascular risk factors, including reduced LDL cholesterol levels, lower blood pressure, and improved glucose control. Additionally, participants in the intervention group reported higher adherence to lifestyle changes and greater overall well-being compared to the control group.
Conclusion:
Limited resources for new health services are a global problem that provides a rationale for adaptive international collaboration in this promising new comprehensive chest CT screening process. AGILE works to engage relevant stakeholders from the medical community, innovative screening research leaders, advocacy group, national health policy leaders and the public at-large regarding opportunities to advance comprehensive chest CT screening and communicate about its benefits and...